Taurine extends healthy life expectancy. In the image, the bull represents taurine (the word taurine comes from Taurus bull; urine, because it was first identified in bull urine), which reverses the aging clock, increasing health and longevity. Credit: Columbia University Irving Medical Center
Research from[{” attribute=””>Columbia University suggests that a deficiency in the nutrient taurine may drive aging in animals, with supplementation showing the potential to slow aging and extend healthy lifespans. The study found taurine levels decreased significantly with age and supplementation led to substantial health improvements in mice and monkeys. Human trials are needed to confirm these findings.
A deficiency of taurine—a nutrient produced in the body and found in many foods—is a driver of aging in animals, according to a new study led by Columbia researchers and involving dozens of aging researchers around the world.
Taurine is a common ingredient in energy drinks, including brands like Red Bull, Monster Energy, Rockstar, NOS, Full Throttle, and AMP. Taurine supplement pills are also available, providing the nutrient without the caffeine, sweeteners, and other ingredients in energy drinks.
The same study also found that taurine supplements can slow down the aging process in worms, mice, and monkeys and can even extend the healthy lifespans of middle-aged mice by up to 12%.
The study was published on June 8 in the journal Science.
“For the last 25 years, scientists have been trying to find factors that not only let us live longer but also increase our health span, the time we remain healthy in old age,” says the study’s leader, Vijay Yadav, PhD, assistant professor of genetics and development at Columbia University Vagelos College of Physicians and Surgeons.
“This study suggests that taurine could be an elixir of life within us that helps us live longer and healthier lives.”
Taurine supplementation increases a healthy life span. In the illustration, an old man is seen walking through a taurine shower and coming out as a rejuvenated, healthy man. The taurine structure is depicted as a ball-and-stick model in the taurine shower. Credit: Columbia University Irving Medical Center
Anti-aging molecules within us
Over the past two decades, efforts to identify interventions that improve health in old age have intensified as people are living longer and scientists have learned that the aging process can be manipulated.
Many studies have found that various molecules carried through the bloodstream are associated with aging. Less certain is whether these molecules actively direct the aging process or are just passengers going along for the ride. If a molecule is a driver of aging, then restoring its youthful levels would delay aging and increase our health span—the number of years we spend in good health.
A study by Columbia researchers found that a lack of taurine, a molecule produced in our bodies, promotes aging and that taurine supplements can improve animal health and increase lifespan. Credit: Columbia University Irving Medical CenterTaurine first came to Yadav’s attention through earlier research on osteoporosis, which revealed taurine’s role in bone formation. Around the same time, other researchers found taurine levels correlated with immune function, obesity, and nervous system function.
“We realized that if taurine regulates all of these processes that decline with age, perhaps taurine levels in the blood have an impact on overall health and lifespan,” says Yadav.
Taurine makes animals healthier and live longer. Credit: Columbia University Irving Medical Center
Taurine declines with age, and supplements increase lifespan in mice
First, Yadav’s team examined taurine levels in the blood of mice, monkeys, and humans and found that taurine abundance declines significantly with age. In humans, taurine levels in 60-year-olds were only about one-third of those in 5-year-olds.
“That’s when we started asking whether taurine deficiency is a driver of the aging process, and we started a big experiment in mice,” says Yadav.
The researchers started with nearly 250 14-month-old female and male mice (about 45 years old in human terms). Each day, the researcher fed half of them a bolus of taurine or a control solution. At the end of the experiment, Yadav and his team found that taurine increased the average lifespan of female mice by 12% and male mice by 10%. For mice, that meant three to four extra months, equivalent to about seven to eight human years.
Taurine levels decrease with age. Credit: Columbia University Irving Medical Center
Taurine supplements in middle age improve health in old age
To learn how taurine affected health, Yadav invited other aging researchers who had studied the effects of taurine supplementation on health and life expectancy in several countries.[{” attribute=””>species.
These experts measured various health parameters in mice and found that at age 2 (60 in human years), animals supplemented with taurine for one year were healthier in almost every way than their untreated counterparts.
The researchers found that taurine suppressed age-associated weight gain in female mice (even in “menopausal” mice), increased energy expenditure, increased bone mass, improved muscle endurance and strength, reduced depression-like and anxious behaviors, reduced insulin resistance, and promoted a younger-looking immune system, among other benefits.
“Not only did we find that the animals lived longer, we also found that they’re living healthier lives,” Yadav says.
Taurine deficiency is associated with poor health. Credit: Columbia University Irving Medical Center
At a cellular level, taurine improves many functions that usually decline with age: The supplement decreased the number of “zombie cells” (old cells that should die but instead linger and release harmful substances), increased survival after telomerase deficiency, increased the number of stem cells present in some tissues (which can help tissues heal after injury), improved the performance of mitochondria, reduced DNA damage, and improved the cells‘ ability to sense nutrients.
Similar health effects of taurine supplements were seen in middle-aged rhesus monkeys, which were given daily taurine supplements for six months. Taurine prevented weight gain, reduced fasting blood glucose and markers of liver damage, increased bone density in the spine and legs, and improved the health of their immune systems.
A bout of exercise increases taurine levels. Credit: Columbia University Irving Medical Center
A randomized clinical trial needed
The researchers do not know yet if taurine supplements will improve health or increase longevity in humans, but two experiments they conducted suggest taurine has potential.
In the first, Yadav and his team looked at the relationship between taurine levels and approximately 50 health parameters in 12,000 European adults aged 60 and over. Overall, people with higher taurine levels were healthier, with fewer cases of type 2 diabetes, lower obesity levels, reduced hypertension, and lower levels of inflammation. “These are associations, which do not establish causation,” Yadav says, “but the results are consistent with the possibility that taurine deficiency contributes to human aging.”
The second study tested if taurine levels would respond to an intervention known to improve health: exercise. The researchers measured taurine levels before and after a variety of male athletes and sedentary individuals finished a strenuous cycling workout and found a significant increase in taurine among all groups of athletes (sprinters, endurance runners, and natural bodybuilders) and sedentary individuals.
“No matter the individual, all had increased taurine levels after exercise, which suggests that some of the health benefits of exercise may come from an increase in taurine,” Yadav says.
Only a randomized clinical trial in people will determine if taurine truly has health benefits, Yadav adds. Taurine trials are currently underway for obesity, but none are designed to measure a wide range of health parameters.
Other potential anti-aging drugs—including metformin, rapamycin, and NAD analogs—are being considered for testing in clinical trials.
“I think taurine should also be considered,” Yadav says. “And it has some advantages: taurine is naturally produced in our bodies, it can be obtained naturally in the diet, it has no known toxic effects (although it’s rarely used in concentrations), and it can be boosted by exercise.
“Taurine abundance goes down with age, so restoring taurine to a youthful level in old age may be a promising anti-aging strategy.”
Reference: “Taurine deficiency as a driver of aging” by Parminder Singh, Kishore Gollapalli, Stefano Mangiola, Daniela Schranner, Mohd Aslam Yusuf, Manish Chamoli, Sting L. Shi, Bruno Lopes Bastos, Tripti Nair, Annett Riermeier, Elena M. Vayndorf, Judy Z. Wu, Aishwarya Nilakhe, Christina Q. Nguyen, Michael Muir, Michael G. Kiflezghil, Anna Foulger, Alex Junker, Jack Devine, Kunal Sharan, Shankar J. Chinta, Swati Rajput, Anand Rane, Philipp Baumert, Martin Schönfelder, Francescopaolo lavarone, Giorgia di Lorenzo, Swati Kumari, Alka Gupta, Rajesh Sarkar, Costerwell Khyriem, Amanpreet S. Chawla, Ankur Sharma, Nazan Sarper, Naibedya Chattopadhyay, Bichitra K. Biswal, Carmine Settembre, Perumal Nagarajan, Kimara L. Targoff, Martin Picard, Sarika Gupta, Vidya Velagapudi, Anthony T. Papenfuss, Alaattin Kaya, Miguel Godinho Ferreiral, Brian K. Kennedy, Julie K. Andersen, Gordon J. Lithgow, Abdullah Mahmood Ali, Arnab Mukhopadhyay, Aarno Palotie, Gabi Kastenmiller, Matt Kaeberlein, Henning Wackerhage, Bhupinder Pal and Vijay K. Yadav, 9 June 2023, Science.
DOI: 10.1126/science.abn9257
This work was funded by the Nathan Shock Center of Excellence in the Basic Biology of Aging Project; National Institutes of Health (R01HD107574, P30AG013280, T32AG066574); Wellcome (098051); Deutsche Forschungsgemeinschaft (450149205-TRR333/1); Institut National Du Cancer (PLBIO21-228); Science and Engineering Research Board (STR/2019/00064); Department of Biotechnology (BT/PR40325/BTIS/137/1/2020); a Longevity Impetus Grant; Academy of Finland Center of Excellence in Complex Disease Genetics (312074, 336824, and 352793); The Sigrid Juselius Foundation; a Larry L. Hillblom Foundation Fellowship; Victorian Cancer Agency (ECRF21036 and MCRF21002); and a DBT Ramalingaswamy Fellowship.
Columbia University has filed provisional patent applications on which Vijay Yadav is listed as an inventor. The remaining authors declare no competing interests.